First registered Epimimetic for urinary wellness combining antibacterial effect, renal protection and no induction of antibiotic resistance

We must be aware of the current problems and the social and health impact on the health of people and animals caused by the misuse or unnecessary abuse of antibiotics, as well as the risk of cross-resistance resulting from their indiscriminate use. In this sense, Naturemimetix offers society the fruit of its research and development inspired by Nature, with the aim of providing innovative solutions to unmet needs and problems in the field of urinary system well-being.

Beyond the obvious strategies aimed at preventing disease or the risk of infection (hygiene measures, development of sensitivity tests, rapid diagnostic methods, etc.), Itxasol® represents a natural and sustainable antibacterial solution that avoids the appearance of resistances.

Itxasol® is a formulation made up of complex molecules of natural origin that contribute synergistically to the well-being of the urinary system and support the normal function of the bladder, being useful for the physiology of this organ and for the maintenance of its ecosystem and urinary flow. It also contributes to the body’s defences against external agents.

Epimimetic is a product, process or service inspired by research into Nature that is combined for its development with knowledge, technology and human values.

Itxasol, the paradigm shift

Patented extract UMB-660®

Itxasol® is the first registered Epimimetic product. Its action is based on different synergistic mechanisms promoted by the patented extract UMB-660® and N-acetyl L-cysteine (NAC).

Unprecedented quality and precision

Itxasol® contains 770 mg of 3 active ingredients per capsule, guaranteeing quality and precision.
Never before has Nature’s research protected human health so much, nor has mankind ever respected Nature so much as with the development of Epimimetic products.

Human knowledge inspired by Nature

Largely due to inappropriate and indiscriminate use, antibiotics are losing efficacy at an unprecedented rate, which has been exacerbated exponentially in the last five years and especially during the SARS-COV-2 pandemic. Uncontrolled antibiotic use at a rate similar to the current rate will bring with it resistant bacterial diseases that will return the advances made over centuries to an era that cannot be tolerated, where diseases now common and easily eradicated could become deadly.

Studies predict around 40,000 deaths by 2050 if the situation is not reversed quickly. Complex medical treatments such as surgeries, transplants or cancer therapies could be seriously compromised if the improper use of antibiotics generates antibiotic resistance that prevents their efficacy.

Itxasol® proposes a totally natural solution that is already a reality of Spanish R&D&I, materialised in an innovative antibacterial product that nips in the bud all the problems of resistance added to the use of conventional antibiotics, opening a new era in the wellbeing of the urinary system and the protection of its ecosystem.

Itxasol bienestar urinario
  • First registered Epimimetic product on the market as a result of Spanish R&D&I.

  • Very high activity: >95% of natural active ingredients with high bioavailability in the urinary tract. Rigorous synthesis, production and quality assurance procedures of the Celavista Mito-Biogenesis laboratory.
  • Recognisable efficacy. Immediate activity that is perceived from the first few doses, sustained and multifactorial.
  • Avoids the appearance of resistance (unlike many antibiotics).
  • Non-toxic. Safety, protection of the urinary system and regenerative health.
  • Does not release residues, thus respecting individual ecosystems (intestinal, vaginal, urinary microbiota, etc.) and the environment.
  • Compliance with GMP and ISO 9001 standards, together with additional safety procedures that go beyond the usual regulations for organic and vegan products. Eco-design, Eco-efficiency and maximum Eco-sustainability. Free of heavy metals and pesticides.

Human knowledge inspired by Nature’s strategy guarantees us, through Itxasol® and these new Epimimetics, the most appropriate concentrations and activities of the molecules to promote human health.

Our Pharmaceutical Technology applied to active ingredients of natural origin allows us to obtain optimum concentrations. It is a pharmaceutical development, which takes into account different factors such as absorption, bioavailability and purity. All of this translates into extremely precise efficacy and safety, as we know and have studied a multitude of active ingredients derived from different plants at the level of different tissues, human and animal pathologies, genera and microbiota, in order to design, research, develop, produce and market Itxasol®, the first Epimimetic.

Unlike other nutraceutical products or food supplements, Epimetic products present high scientific evidence supported by publications, maximum precision in terms of their components, formulation, concentration and bioavailability of active ingredients (vegan and gastroresistant capsules), at the recommended doses.

Itxasol resistencia antibioticos

A Natural Alternative Treatment for Urinary Tract Infections: Itxasol©, the Importance of the Formulation

by José M. Cela-López, Claudio J. Camacho Roldán, Gorka Gómez-Lizarraga and Vicente Martínez
Naturemimetix, UPV/EHU Science Park, Edificio Sede Barrio Sarriena s/n, 48940 Leioa, Vizcaya, Spain
Author to whom correspondence should be addressed.
Academic Editor: Simona Collina
Molecules 2021, 26(15), 4564;
Received: 20 June 2021 / Revised: 13 July 2021 / Accepted: 26 July 2021 / Published: 28 July 2021
(This article belongs to the Section Medicinal Chemistry)

Effects of Itxasol© Components on Gene Expression in Bacteria Related to Infections of the Urinary Tract and to the Inflammation Process

by José M. Cela-López , Claudio J. Camacho Roldán , Gorka Gómez-Lizarraga and Vicente Martínez
Celavista, Parque Científico de la UPV/EHU, Edificio Sede, Barrio Sarriena, s/n, 48940 Leioa, Bizkaia, Spain
Naturemimetix, Parque Científico de la UPV/EHU, Edificio Sede, Barrio Sarriena, s/n, 48940 Leioa, Bizkaia, Spain
Author to whom correspondence should be addressed.
Academic Editor: Grzegorz Wegrzyn
Int. J. Mol. Sci. 2021, 22(23), 12655; (registering DOI)
Received: 29 September 2021 / Revised: 16 November 2021 / Accepted: 18 November 2021 / Published: 23 November 2021
(This article belongs to the Section Molecular Genetics and Genomics)

(*) The formulation of Itxasol® contributes to the well-being of the urinary system thanks to the action of Arctostaphylos uva-ursi. This compound also supports normal bladder function, being useful for bladder function and urinary flow. It also contributes to the body’s defences against external agents.



Celavista Mito-Biogénesis